Male patient with mild cognitive impairment and extremely high P300 and Slow-wave latencies: a case report

doi:10.4076/1757-1626-2-6157

Cases Journal

Volume 2

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Tsolaki MN
Kimiskidis VK
Anogianakis G

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Anogianakis G
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Case Report

Male patient with mild cognitive impairment and extremely high P300 and Slow-wave latencies: a case report

Vasileios T Papaliagkas¹, Magda N Tsolaki², Vasileios K Kimiskidis² and Georgios Anogianakis¹

¹Department of Experimental Physiology, Aristotle University of Thessaloniki, Thessaloniki, Greece

²Third Department of Neurology, Aristotle University of Thessaloniki, "G. Papanikolaou" Hospital, Thessaloniki, Greece

Cases Journal 2009, 2:6157doi:10.4076/1757-1626-2-6157


Published:	1 July 2009

Abstract

We present a case of a 74-year-old Greek male who suffered from paraphasias, memory and orientation problems. The patient was assessed with neuropsychometric tests, auditory event-related potentials and cerebrospinal fluid proteins and was diagnosed with mild cognitive impairment. The emphasis on the case is on the unexplained high levels of P300 and Slow wave of the auditory event-related potentials.

P300 is believed to be delayed in Alzheimer's Disease (AD), however in our case it was extremely prolonged in baseline and follow-up examinations without AD being diagnosed. This might suggest that AD is a complex and multifactorial disease.